Endocrine Abstracts

Introduction: Autoimmune Thyroid Diseases (AITD) are one of the most prevalent autoimmune diseases in industrialized countries (5% of population). The two main phenotypes of AITD, Hashimoto thyroiditis (HT) and Graves’ disease (GD), are both characterized by the presence of circulating thyroid antibodies and infiltration by autoreactive lymphocytes in the thyroid gland and sometimes the orbit. One of the most studied mechanisms underlying AITD is the imbalance between imm...

Introduction: Autoimmune thyroid diseases (AITD) such as Graves’ disease (GD) or Hashimoto’s thyroiditis (HT) are autoimmune, organ-specific diseases probably related to a complex and multifactorial interplay of specific susceptibility genes and environmental exposures. T lymphocytes and their secretory cytokines play indispensable roles in disrupting tolerance. However, their roles are often complex and full of interactions among distinct components of the thyroid e...

Context: Pathological transcriptomic landscape has been the driver of the Molecular Biology in the recent years. Massive RNA sequencing techniques have been extended from bulk RNAseq, to single cell sequencing (scRNAseq) and spot-based spatial transcriptomics (ST), and sometimes laboratory cannot afford all of them. We tried to answer the question about which would be the best option in thyroid gland using Hashimoto’s thyroiditis (HT) context.Method...